The German Cancer Research Center is the largest biomedical research institution in Germany. With approximately 3,000 employees, we operate an extensive scientific program in the field of cancer research.
For the partner site Dresden of the National Center for Tumor Diseases (NCT) the German Cancer Research Center (DKFZ) is seeking a
The National Center for Tumor Diseases (NCT, Dresden) offers a PhD position in the field of cancer immunology.
The immune system plays a vital role in providing defense against a vast array of potential pathogens. Dysfunction of the immune system is implicated in diverse human diseases including cancer. The ability of neoplastic cells to attenuate immune attack and achieve immune resistance is a key step in tumorigenesis. Remarkable advances have been made in directing the immune system to target tumor cells and first immune therapies enter clinical routine. However, the molecular basis of immune resistance is not fully understood. Our research strives to explore new strategies for immune therapy of cancer. We develop and apply methods of reverse genetics such as CRISPR / Cas9-based genome editing or RNA interference in human tissue culture cells to identify genes implicated in immune resistance. To reach this goal, we utilize cell-based high-throughput screening methods and characterize underlying molecular mechanisms by applying a broad spectrum of scientific techniques from the fields of cell- and molecular biology and bioinformatics.
We are an enthusiastic team and offer intensive training and mentoring. The proximity to the University Hospital of Dresden opens up manifold possibilities for collaborations and allows studying newly identified regulators in a unique environment.
Diploma or master‘s degree in life sciences such as biology, molecular medicine or related fields. Experience in cell- or molecular biology techniques including functional genomics, genome-editing, RNA interference and screening is highly desirable but not essential. Successful candidates will be working in an international environment and proficiency in both written and oral English is required.
The position is limited to 3 years.
For further information please contact
Dr. Heidrun Groß, phone +49 351 458-5239, Mandy Erlitz, phone +49 351 463-40277.