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1 PhD position in Cell biology / Biochemistry, Jena University Hospital ‐ Friedrich Schiller University Jena, Germany

We seek for a productive addition to our team. Applicants should have solid theoretical and practical knowledge of cell/neurobiology, biochemistry and/or imaging techniques. Candidates need to be distinguished by high motivation to succeed in science and by being kind, efficient and reliable team‐players able to integrate into our team smoothly. Due to the internationality of our group and of the lively university town of Jena knowledge of the German language is not required. Fluent English is a prerequisite.

 

The aim of our internationally well‐known research team (see e.g. PubMED and ResearchGate) is to gain a molecular understanding of how the topologies and shapes of the plasma membrane, cellular compartments and entire cells that are required for their biological functions are brought about and how such membrane shaping processes contribute to development, plasticity and function of cells and cellular networks, such as those formed by neurons in the brain. For overview and methods we apply please e.g. see Ahuja et al. 2007 Cell;  Dharmalingam et al. 2009 J Neurosci.;  Koch et al. 2011 EMBO J;  Schwintzer et al. 2011 EMBO J;  Schneider et al. 2014 J Cell Biol; Hou et al. 2015 PLoS Biology ; Seemann et al. 2017 eLIFE ; Izadi et al. 2018 J Cell Biol ; Haag et al. 2018 Cell Reports and Hou et al. 2018 Dev Cell .

 

The Project:

The polar and extremely arborized morphologies that neurons develop are a prerequisite for signal processing in neuronal networks. Their development seems to be promoted by local Ca2+ signals, actin filament formation and proteins that modulate the local topology of membrane areas by their association. Besides proteins of the syndapin family (Reviews: Kessels & Qualmann 2015 J Cell Sci; Qualmann et al.  2011 EMBO J) and of actin nucleators, such as Cobl (Reviews: e.g. Izadi et al. 2018BBRC; Qualmann & Kessels 2009 Trends Cell Biol), the project aims at studying the membrane interactions and the cell shape-changing potential of further proteins we have identified as membrane shapers as well as their regulation and their interplay with further cellular components, in particular those of the cytoskeleton.

By applying biochemical, cell biological, genetic and modern imaging and ultra-high resolution imaging techniques we reach detailed insights into how cells develop, maintain and modulate the specific and often very much specialized morphologies required for their physiological function.

 

The position: 3 years 50% TV-L E13 (salary for public service employees; i.e. 50% of postdoc salary).

If required, an elongation for finishing the PhD may be possible.

For further information: https://www.uniklinikum-jena.de/biochemie/en/Biochemistry+I/Job+offers.html

Please direct your complete application (cover letter, CV, certificates incl. grades (and an explanation/decoding of the grading system used)); list of publications & honours; 2‐3 ref. addresses) to

 

Prof. Dr. Britta Qualmann & PD Dr. Michael M. Kessels

Institute of Biochemistry I, Jena University Hospital ‐ Friedrich Schiller University Jena

Nonnenplan 2‐4, D‐07743 Jena, Germany

Please submit your application by E‐mail to Michael.Kessels@med.uni‐jena.de(PDFs preferred)

 

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