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Funded PhD position; in vesicle transport and membrane dynamics in neurons; at Institute for Molecular Cell Biology; University of Münster; in Germany

The Institute for Molecular Cell Biology at the University of Münster is looking for
PhD students (TVL-13 65%, 3 years starting January 2018 or later) to investigate

Vesicle transport and membrane dynamics in neurons

The precise temporal and spatial regulation of membrane dynamics is essential for the differentiation and normal function of neurons. Defects in the pathways that regulate the intracellular transport of vesicles or endo- and exocytosis disrupt cortical development and lead to neurodevelopmental diseases. We are interested in the molecular and cellular mechanisms of polarized transport and exocytosis and the formation of membrane domains during axon extension and neuronal migration.
The project focuses on the question how different GTPases regulate vesicle transport and endo- and exocytosis and includes the development of optogenetic tools and genetically encoded sensors to analyze intracellular transport and membrane dynamics by live cell imaging.

We are looking for highly motivated candidates with an interest in understanding fundamental questions of neurobiology at the molecular and cellular level. The project will employ a combination of molecular, cell biological, and genetic techniques in combination with life cell imaging to study differentiation in cultured neurons and organotypic slice cultures from knockout mice.
The position is available initially for 3 years starting January 2018 or later.
Experience in molecular biology, cell culture or life cell imaging is desirable. We offer an international environment with English as the language spoken in the laboratory. The project is part of the Cluster of Excellence “Cells in Motion”. The University of Münster is an equal opportunity employer.

For an overview of ongoing projects visit:
http://www.imprs-mbm-cedad.mpg.de/index.php?page=project&id=22
http://www.uni-muenster.de/Biologie.AllgmZoo/Gruppen/Pueschel/index.html

Publications:
Shah, B. et al. (2017). Rap1 GTPases Are Master Regulators of Neural Cell Polarity in the Developing Neocortex. Cereb. Cortex 27, 1253–1269.

Shah, B. et al. (2016). C3G/Rapgef1 is Required in Multipolar Neurons for the Transition to a Bipolar Morphology during Cortical Development. PLoS One 11, e0154174.

Send application to

Applications (including CV, a brief summary of the Master’s project and Transcript of Records) can be sent by
e-mail until October 30 to apuschel@uni-muenster.de

Prof. Andreas Püschel
Institute for Molecular Cell Biology
University of Münster
Schlossplatz 5
48149 Münster
Germany

Deadline: October 30, 2017.

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